The guaiac-based fecal occult blood test (gFOBT) is a widely used screening tool for the early detection of colorectal cancer. This non-invasive test involves collecting small samples of stool and applying them to a test card that contains a chemical called guaiac. When guaiac comes into contact with blood, it produces a blue color, indicating the presence of blood in the stool. The main idea of the guaiac-based fecal occult blood test is to detect hidden blood in the stool, which can be a sign of colorectal cancer or other gastrointestinal conditions. The test is typically recommended for individuals who are at average risk for colorectal cancer and should be performed every one or two years, depending on the specific guidelines in place. It is important to note that a positive guaiac-based fecal occult blood test does not necessarily mean that a person has colorectal cancer.
It is important to note that a positive guaiac-based fecal occult blood test does not necessarily mean that a person has colorectal cancer. There are several factors that can cause blood to be present in the stool, including hemorrhoids, ulcers, and certain medications. However, a positive test result should be followed up with further diagnostic tests, such as a colonoscopy, to determine the cause of the bleeding.
Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review
Objective: To determine the accuracy of guaiac and immunochemical faecal occult blood tests (FOBTs) for the detection of colorectal cancer in an average-risk screening population.
Methods: Fifteen electronic databases, the internet, key journals and reference lists of included studies were searched. We included diagnostic accuracy studies that compared guaiac or immunochemical FOBTs with any reference standard, for the detection of colorectal cancer in an average-risk adult population, with sufficient data to construct a 2 x 2 table.
Results: Fifty-nine studies were included. Thirty-three evaluated guaiac FOBTs, 35 immunochemical FOBTs and one evaluated sequential FOBTs. Sensitivities for the detection of all neoplasms ranged from 6.2% (specificity 98.0%) to 83.3% (specificity 98.4%) for guaiac FOBTs, and 5.4% (specificity 98.5%) to 62.6% (specificity 94.3%) for immunochemical FOBTs. Specificity ranged from 65.0% (sensitivity 44.1%) to 99.0% (sensitivity 19.3%) for guaiac FOBTs, and 89.4% (sensitivity 30.3%) to 98.5% (sensitivity 5.4%) for immunochemical FOBTs. Diagnostic case-control studies generally reported higher sensitivities. Sensitivities were higher for the detection of CRC, and lower for adenomas, in both the diagnostic cohort and diagnostic case-control studies for both guaiac and immunochemical FOBTs.
Conclusions: Immudia HemSp appeared to be the most accurate immunochemical FOBT, however, there was no clear evidence to suggest whether guaiac or immunochemical FOBTs performed better, either from direct or indirect comparisons. Poor reporting of data limited the scope of this review, and the use the Standards for Reporting of Diagnostic Accuracy guidelines is recommended for reporting future diagnostic accuracy studies.
The guaiac-based fecal occult blood test is a relatively inexpensive and simple screening tool that can be performed in the privacy of one's own home. However, it is important to follow the instructions carefully to ensure accurate results. For example, certain foods and medications can interfere with the test and lead to false positive or false negative results. Overall, the guaiac-based fecal occult blood test plays a crucial role in the early detection of colorectal cancer. By identifying hidden blood in the stool, this screening tool allows for early intervention and treatment, ultimately improving outcomes for individuals with colorectal cancer. It is important for individuals to discuss their screening options with their healthcare provider to determine the best approach for their specific situation..
Reviews for "Guaiac-Based Fecal Occult Blood Testing for Surveillance of Colorectal Cancer"
1. Emily - 2/5
I recently had to take a Guaiac based fecal occult blood test and I have to say, I was not impressed. The test itself was messy and unpleasant. Having to smear a sample of my own poop onto a card was not something I enjoyed doing. Additionally, the test results were inconclusive and I had to go through further testing which was even more invasive and uncomfortable. Overall, I would not recommend this test to anyone.
2. Mike - 1/5
I had the unfortunate experience of taking the Guaiac based fecal occult blood test and it was a nightmare. The test was not only messy but also incredibly unreliable. I followed all the instructions carefully but still received a false-positive result, which caused unnecessary anxiety and stress. The process of collecting the sample itself was unpleasant and humiliating. I believe there are better and more reliable screening options available, and I would not recommend this test to anyone.
3. Sarah - 2/5
I recently underwent the Guaiac based fecal occult blood test, and I found the entire process quite cumbersome. The kit provided for collection was difficult to use, and obtaining a proper sample was a messy and unpleasant experience. Moreover, the test results took longer than anticipated, causing unnecessary anxiety during the waiting period. Overall, I was not satisfied with this test and would suggest exploring alternative options for regular screenings.